Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

CE Thomas; P Georgeson; C Qu; RS Steinfelder; DD Buchanan; M Song; TA Harrison; CY Um; MA Hullar; MA Jenkins; B Van Guelpen; BM Lynch; YA Melaku; JR Huyghe; EK Aglago; SI Berndt; LA Boardman; PT Campbell; Y Cao; AT Chan; DA Drew; JC Figueiredo; AJ French; M Giannakis; EL Goode; SB Gruber; A Gsur; MJ Gunter; M Hoffmeister; L Hsu; WY Huang; V Moreno; N Murphy; PA Newcomb; CC Newton; JA Nowak; M Obón-Santacana; S Ogino; W Sun; AE Toland; QM Trinh; T Ugai; SH Zaidi; U Peters; AI Phipps

Journal article

Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

CE Thomas, P Georgeson, C Qu, RS Steinfelder, DD Buchanan, M Song, TA Harrison, CY Um, MA Hullar, MA Jenkins, B Van Guelpen, BM Lynch, YA Melaku, JR Huyghe, EK Aglago, SI Berndt, LA Boardman, PT Campbell, Y Cao, AT Chan Show all

Cancer Epidemiology Biomarkers and Prevention | Published : 2024

DOI: 10.1158/1055-9965.EPI-23-0600

Abstract

Background: The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors’ association with colorectal cancer risk and survival differs by SBS88. Methods: Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer–specific survival using Cox proportional hazards regression (N = 3,..

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University of Melbourne Researchers

Peter Georgeson Author

Daniel Buchanan Author

Mark Jenkins Author

Brigid Lynch Author

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Awarded by Centers for Disease Control and Prevention

Funding Acknowledgements

Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO): National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services (U01 CA137088, R01 CA059045, U01 CA164930, R21 CA191312, R01 CA244588, R01 CA206279, R01 CA201407, R01 CA488857, and P20 CA252733). Genotyping/Sequencing services were provided by the Center for Inherited Disease Research (CIDR) contract number HHSN268201700006I and HHSN268201200008I. This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA015704. Scientific Computing Infrastructure at Fred Hutch funded by ORIP grant S10OD028685. C.E. Thomas is supported by L70 CA284301, T32 CA094880, and T32 CA009168.